An unusual syndrome of hemolytic anemia, thrombocytopenic purpura and renal disease.

By CLA1 E N. SHUMWAY, ,JR. AND GF 1t. L1 \IILLE1t T lIE “HE 1oL TIc-[I F I1’ $YNI)ROME” is the tiarne suggested by Gasser et a!.’ for an illness of unknown etiology (haracterized by hemo1yti anemia, t hromhoeyt opeilia ai id renal in uffieietwy . Five rapidly fatal a e orcurring iii Childhood were de ciibed by these authors. Rerently A1li on2 (Ie 4(’rihed six infants with sii ilar (lilIi(al findings. A patient with a coi parable but less rapidly fatal illness was reported by I)acie et al.3 as an example of atypical congenital hemolytic anemia with nephritis. It is the purpose of this paper to describe observations made of a child with a similar and possibly identical disease process. Attention is called to the relation of the disorder to infection and to the remarkable changes in ervthrocvte morphology which accompanied the hemolytic episodes.